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Effexor

The Effexor injury case attorneys at the Drug Law Center have successfully resolved many antidepressant lawsuits and compensation claims after our clients suffered mild to severe injuries.

Introduction

Effexor  Drug RecallThe popular anti-depressant medication Effexor (venlafaxine HCI), manufactured, marketed, and promoted by pharmaceutical giant Pfizer, Inc. has generated more than $3 billion in sales annually worldwide. The medication is classified as an SSNRI (selective serotonin and norepinephrine uptake inhibitor). Both the brand-name Effexor and its generic form venlafaxine HCI effects specific chemicals in the brain that might be unbalanced and individuals suffering from depression. Almost since it was first introduced in the medical marketplace, doctors have prescribed Effexor to treat panic disorder, anxiety, and major depressive disorder. Almost since its initial launch, Effexor (venlafaxine HCI) has been better at treating depression compared to the competition. However, it also likely has greater side effect incident rates were many patients experience withdrawal symptoms.

The History of Effexor

Wyeth Pharmaceuticals scientist first synthesized venlafaxine HCI in the early 1980s. It was soon discovered to be an effective treatment of depression. In 1994, the company promoted the brand-name Effexor and the generic form venlafaxine HCI after approval from the Food and Drug Administration (FDA).

By 1997, the company sold Effexor ER (the extended-release formulation) after approval by the FDA. It was prescribed as a single dose taking each day, which produced slightly lower nausea rates, especially when the therapy was just beginning.

To date, the Food and Drug Administration has approved the medication to treat major depressive disorder, panic disorder, social anxiety disorder, and GAD (generalized anxiety disorder). However, some doctors prescribed the medication for off-label uses that include:

  • PTSD (posttraumatic stress disorder)
  • Fibromyalgia
  • Classes
  • Chronic pain syndrome
  • Migraine prophylaxis
  • Diabetic neuropathy
  • Irritable bowel syndrome (IBS)
  • Fatigue syndrome
  • Tension-type headaches
  • Bipolar depression
  • Cocaine dependency
  • Attention deficit hyperactivity disorder (ADD/ADHD)
  • Premenstrual dysphoric disorder (PMDD)

The Advantages and Disadvantages of Effexor

Now that the medication has been in use for over two decades, there are significant advantages and disadvantages to taking Effexor. Some of these include:

  • Significant Advantages:
    • Effexor (venlafaxine HCI) is thought to be highly effective, compared to SSRIs (selective serotonin reuptake inhibitors) in treating major depression
    • Research indicates that Effexor (venlafaxine HCI) produces exceedingly high therapeutic success rates
    • Has been proven to be effective when SSRIs are unresponsive to treat a case of depression
    • Tends to improve memory
    • Has better remission rates than paroxetine and fluoxetine
    • Seems to have recurrence prevention properties
    • Seems to be highly effective for quick onset of anxiolytic and antidepressant activities
  • Significant Disadvantages:
    • Many patients experience withdrawal syndrome even after missing just one dose. This is thought to occur because venlafaxine HCI has a short half-life.
    • Is highly toxic when overdosed, especially compared to SSRIs (selective serotonin reuptake inhibitors)
    • Can cause elevated blood pressure
    • Has a higher incident rate of causing vomiting and nausea
    • Is known to have a high potential risk of suicide

Effexor Withdrawal Symptoms

Many patients experience severe withdrawal symptoms when they stop taking Effexor (venlafaxine HCI). The most common symptoms include irritability, vomiting, nausea, nightmares, paresthesia (a tingling, prickly sensation on the skin), headaches, and feeling dizzy. Many of these withdrawal symptoms occur just hours after reducing or stopping the usual dose of Elektra plus. Because of that, drivers and those operating machines are urged to stop that activity or adhere to a strict drug routine that can minimize the potential of experiencing withdrawal symptoms.

Effexor Side Effects

Like all other medications and over-the-counter remedies, Effexor has serious side effects that should be considered before, during and after taking the drug. However, the many side effects caused by Effexor (venlafaxine HCI) often do not require medical attention. This is because the body normally adjusts to the medication quickly and the side effects can go away over time. However, some significant major side effects require immediate medical attention.

The mildest side effects that Effexor (venlafaxine HCI) produces include:

  • Runny or stuffy nose
  • Gas or stomach pain
  • Loss of appetite
  • Heartburn
  • Drowsiness
  • Diarrhea
  • Reduced libido (diminished sexual drive or ability)
  • Difficulty in sleeping
  • Weight loss
  • Unusual weakness or tiredness
  • Constipation or diarrhea
  • Abnormal dreams

However, there are serious to severe major side effects that Effexor produces that could affect the health and well-being of the patient. More common major side effects include:

  • High blood pressure
  • Excessive sweating
  • Loss or diminished strength
  • Severe headaches

Less common major side effects involved:

  • Blurry vision
  • Mental or mood changes
  • Irregular fast heartbeat
  • Chest pain
  • Suicidal ideation (thinking about committing suicide)
  • Buzzing or ringing in the ears

There are significant major side effects that rarely occur. These include:

  • Action or behavior that becomes out-of-control
  • Dramatic change in perception
  • Uncoordinated muscular movement
  • Circulatory problems
  • Major irritability
  • Involuntary quivering
  • Stomach cramps
  • Heart rate instability
  • Infrequent or incomplete bowel movements
  • The inability to produce or maintain an erection
  • Ejaculation difficulties
  • Over-responsiveness to reflexes
  • Severe muscle stiffness
  • Menstrual changes
  • Skin rashes and itching
  • Convulsions
  • Gastrointestinal discomfort
  • Low or high blood pressure
  • Fainting or lightheadedness especially when standing suddenly
  • High fever
  • Acting, feeling, or talking that becomes out-of-control
  • Nervousness
  • Effexor Discontinuation Syndrome

Effexor discontinuation syndrome SSRI withdrawal is a common occurrence. Typically, these symptoms tend to be nonspecific and very broad whenever the patient discontinued taking Effexor (venlafaxine HCI). To avoid SSRI discontinuation syndrome, it is important that:

  • Treating physicians should never prescribe Effexor (venlafaxine HCI) to adolescents or children because it increases suicidal ideation (thinking about committing suicide) or self-harm.
  • Effexor is known to increase eye pressure which can be extremely harmful to patients with glaucoma.
  • Taking Effexor (venlafaxine HCI) concomitantly with MAOIs) monoamine oxidase inhibitors is strictly prohibited, doctors are advised to prescribe one medication after the other medication was stopped for at least 14 days.

Effexor Contraindications

Nearly every prescription medication, including Effexor (venlafaxine HCI), will have contraindications, where patient suffering from a medical condition, experiencing symptoms, or taking other medications should avoid taking the antidepressant altogether.

Patients should avoid taking Effexor (venlafaxine HCI) if they suffer from any one of the following:

  • Suicidal ideation (thinking about committing suicide)
  • Had a recent heart attack
  • Suffers from liver problems
  • Was diagnosed with liver hardening
  • Suffers from High Cholesterol
  • Has moderate to severe kidney impairment
  • Was diagnosed with Serotonin Syndrome – Adverse Medication Interaction
  • Suffers from blood clotting disorder
  • Experiences seizures
  • Has been diagnosed with Inappropriate Anti-Diuretic Hormone Secretion syndrome
  • Suffers from severe uncontrolled high blood pressure
  • Has an increased potential risk of bleeding

Lawsuits

Within just a couple of years after the generic version of Effexor, venlafaxine HCI, became available the medical marketplace, plaintiffs for filing lawsuits against Wyeth Pharmaceuticals alleging that the company had misrepresented or exaggerated claims on Effexor’s effectiveness and safety for consumers. Even today, plaintiffs are claiming that the drug is dangerous because it produces suicidal ideation and thoughts of self-harm.

Scientist and doctors have known for a long time that Effexor can produce violent behavior toward others and to the patient taking the medication. In fact, most SSRIs (serotonin reuptake inhibitors) have been known to produce violent occurrences. However, lawyers have often found it difficult to prove the correlation between violent behavior and taking Effexor (venlafaxine HCI) when presenting evidence in court.

Some plaintiffs are claiming that Effexor (venlafaxine HCI) causes birth defects. To date, there are many lawsuits yet to be heard in both federal and state court concerning the correlation between birth defects and taking Effexor (venlafaxine HCI) during pregnancy.

Effexor Lawsuits

  • Pfizer Inc. Facing Baby Heart Defect Effexor Lawsuit

December 2014 – Parents of a son born with serious life-threatening heart defects as files a monetary compensation lawsuit against Pfizer, Inc., the manufacturer of the popular antidepressant Effexor medication. The lawsuit was filed in the U.S. District Court for the Eastern District of Pennsylvania. In February 2010, the plaintiffs’ son was born with significant congenital heart problems. Lawsuit documents reveal that the plaintiffs are claiming the mother’s use of antidepressant medication during her pregnancy caused her son’s defects.

The Missouri couple is seeking monetary recompense to recover their ongoing medical expenses, nursing costs, additional surgeries, off and on hospitalization, constant treatment, pharmaceutical costs, the need for rehabilitation and all other costs that are unforeseeable in the child’s future. Lawyers working on behalf of the Missouri plaintiffs are also asking for punitive damages to hold Pfizer morally accountable for their failure to warn the public of serious birth defects caused by their dangerous drug.

  • Lawsuit Alleges Birth Defect Caused by Mothers Effexor Use

January 2014 – A Minnesota couple has filed suit against Pfizer, claiming the mother’s use of the antidepressant Effexor was linked to her son’s birth defects. The plaintiffs in the case are alleging that Pfizer, Inc. Makers of Effexor (venlafaxine HCI) failed to warn them of the serious side effects of the product including its correlation with birth defects. Lawsuit documents reveal that the suit is based on negligence, failure to warn, and product liability.

Lawyers have built the case on behalf of their plaintiffs by stating that the Minnesota mother had been prescribed and took Effexor during her pregnancy. Since childbirth, the newborn required numerous surgeries to repair multiple defects and will likely require additional surgeries in the years ahead. The plaintiffs are suggesting that had the mother known or been made aware of known Effexor side effects on newborns and fetuses, she would have never taken the medication and likely would have chosen alternative methods for treating her depression.

The plaintiffs are claiming that Pfizer was aware, or should have been aware, that Effexor (venlafaxine HCI) can impact the health of the fetus by crossing through the placenta. Lawsuit documents reveal that animal testing occurring in the mid-1990s directly linked the development of birth defects with taking Effexor.

Let Us Handle Your Effexor Lawsuit Compensation Claim

The Effexor injury case attorneys at the Drug Law Center are currently handling antidepressant lawsuits and optimization claims for victims of Effexor and those who have died because of complications when taking the medication. We accept all medical malpractice, product liability, personal injury, and wrongful death lawsuits on contingency. This means we postpone payment of our legal services and are paid only after we have successfully resolved your case through a negotiated settlement or through a jury trial award.

Contact us today to schedule a comprehensive, free initial consultation. Speak with one of our competent personal injury attorneys who specializes in cases just like yours. You are under no obligation to move forward with your case and all information and evidence you provide our law firm is always kept confidential. We can provide various legal remedies while protecting your rights to receive financial compensation from any party who caused you harm. This could include the pharmaceutical manufacturer, the distributor, the supplier, the hospital, doctor’s office, or health care provider.

Sources:
http://www.clevelandclinic.org/health/health-info/docs/2700/2753.asp?index=8425
http://www.mayoclinic.org/drugs-supplements/venlafaxine-oral-route/description/drg-20067379
https://www.fda.gov/Drugs/DrugSafety/ucm106481.htm
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020699s059lbl.pdf

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